Effectiveness of therapeutic drug monitoring of phenobarbitone in hospitalized epileptic neonates patients / Siti Hajar Jailani

The study was aimed to examine the effectiveness of therapeutic drug monitoring of phenobarbitone on neonates in a hospital setting. The data of patients were collected from Hospital Sultanah Aminah, Johor Baru and comprised of 64 TDM forms with 35 male patients and 29 female patients. The patients' demographics and pharmacokinetics were analysed to observe the pattern correlating to phenobarbitone. The data was then described by a one-compartment model. The analysis showed that there is no significant relationship between race and pharmacokinetic parameters, yet there is weak relationship between gender and some pharmacokinetic parameters. There is moderate relationship between total dose per day and clearance with r2 value ranging from 0.2 to 0.3. Furthermore, total dose per kg is weakly correlated with clearance. The COY value of > l 0% showed high inter-patient variability between variables. Hence, individual monitoring is crucial to achieve the therapeutic goal of phenobarbitone regimen and to avoid toxicity.