Neuroprotective effect of piracetam against LPS-induced neuroinflammation using EOC-20 cells: cell viability / Farah Yasmin Azwan

Alzheimer's disease (AD) is the most common form of dementia that mainly affects the memory and cognitive functions of the brain. Piracetam is one of a nootropic drug that acts as a memory enhancer and its mechanism of action is yet to be known. Piracetam is believed to improve the function of acetylcholine (ACh) as a neurotransmitter via muscarinic cholinergic receptor. The ACh is the one that is responsible for memory and cognitive functions of the brain. The neuroprotective effect of piracetam against neuroinflammation by LPS-induced was determined using EOC-20 cells in this study. The cytotoxicity study of LPS-induced cell showed that it caused tremendous reduction in cell viability. As with piracetam, it does not show any toxicity, but with a lower rate of reduction even at high concentration of piracetam tested. However, the results of the neuroprotective effect by piracetam on LPS-induced cell showed that it protected the cells from toxicity and enhanced the cell viability too. In conclusion, the piracetam exhibited the neuroprotective effect on the LPS-induced using EOC-20 cells.