Nicotinamide supplementation ameliorated glucose homeostasis in STZ+NA induced type II diabetic rats / Muhammad Ridzwan Ramli

Diabetes Mellitus(DM) is a metabolic disease that is associated with hyperglycemic condition which is caused by deficiency in insulin production, resistance toward insulin action or even both(Mayfield, 1998). The syndromes manifested include vascular, metabolic and neuropathic components that are usually interrelated. This ineffective insulin action causes a lot of alteration of metabolic processes in the body(Mayfield, 1998). The most prominent alteration is the metabolism of fats, carbohydrates and proteins. This will eventually leads to the dysfunction of organs such as the eyes, kidneys and blood vessels(Narayan, Boyle, Geiss, Saaddine, & Thompson, 2006).