Ahmad, Afiqah
(2014)
Detection of polymorphisms in exon 2 of human glucocorticoid receptor gene (NR3C1) using polymerase chain reaction (PCR) / Afiqah Ahmad.
Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
Abstract
There are three documented polymorphisms in exon 2 of Human Glucocorticoid Receptor gene (NR3Cl). These include ER22/23EK, N363S and Bell. ER22/23EK induces glucocorticoid resistance while N363S and Bell cause hypersensitivity towards glucocorticoids. A probable novel SNP (C408 l 4T) has been detected in a sample where it produces a synonymous mutation with no change in the amino acid. AS-PCR can be done in the future to screen larger group of samples to validate the presence of this SNP.
Metadata
| Item Type: | Thesis (Degree) |
|---|---|
| Creators: | Creators Email / ID Num. Ahmad, Afiqah UNSPECIFIED |
| Contributors: | Contribution Name Email / ID Num. Thesis advisor Siew, John Shia Kwong UNSPECIFIED |
| Subjects: | R Medicine > RS Pharmacy and materia medica > Materia medica > Pharmaceutical chemistry |
| Divisions: | Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy |
| Programme: | Bachelor of Pharmacy |
| Keywords: | polymorphisms, human glucocorticoid receptor gene (NR3C1), polymerase chain reaction (PCR) |
| Date: | 2014 |
| URI: | https://ir.uitm.edu.my/id/eprint/111123 |
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