Camptothecin loaded egg albumin­ glycine nanoparticles for targeted delivery to colon cancer cells / Nurdini Syairah Md Shah

Cancer is one of the leading causes of death worldwide, accounting for 8.2 million mortality in 2012 ("Globocan 2012 Stats - Global Cancer Rates Continue to Soar"). In Malaysia, cancer is increasing in incidence with an estimated 30 000 annual cases. It is regarded as a giant killer among health diseases ("CARIF - Status of Cancer in Malaysia" 2014). This disease has become a public health burden which significantly affects the development and progress in order to achieve the ultimate goal of a healthy nation (Lim et al., 2003). In Malaysia, colon cancer ranks as the third most common cause of cancer deaths which accounts for 7.8% and 5.6% in males and females respectively. The majority of colon cancer victims are Chinese with J?Ore than 2.5 times the incidence compared to Malays and Indians (Lim et al., 2003; Y ahaya et al., 2002). The risk of developing colon cancer in Asia is mainly influenced by lifestyle and environmental factors such as smoking, obesity, dietary factors, physical inactivity and to some extent, the ethnic background of the patients (Chong et al., 2009; Tsukuma et al., 2011).