Design and synthesis of saclofen zinc (II) complex / Muhammad Al-Wahsi Mohammad Jafri

y-Amino butyric acid (GABA) plays an important role in the migration of neuron where the GABA analogues give effects on 3 types of receptors that are GABAA, GABA8, and GABAc (Behar et al. 1996). GABA predominantly acts as chemoattractant where it involves in the migration and development of the embryonic cortical cells (Behar et al. 2001). GABA is the dominant inhibitor of neurotransmitter in mammalian where it affects the synaptic integration, depolarization of neuron and also the network oscillation that contribute to the functional of cognition in human (Gaiarsa and Porcher 2013).