Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan

Self nanoemulsifying drug delivery system (SN EDDS) is a mixture of concentration of oils, surfactant and co-surfactant to dissolve the poorly soluble drugs (Curcumin). In this study, isopropyl myristate was used as the oil phase, Cremophore RH40 and polyethylene glycol as the surfactant and co-surfactant respectively. The mixture of isopropyl myristate, Cremophore RH40 and polyethylene glycol were allowed to self­ emulsify under gentle agitation. Next, the particle size was measured using Laser diffraction Malvern Mastersizer 2000MU and Malvern Zetasizer Nano ZS. The outcome shows that the ratio of oil, surfactant, and co-surfactant give a large influence to the particle size of the nanoemulsion. Finally, the composition of Cremophore RH40 29%, polyethylene glycol 12% and isopropyl myristate 59% has given the size of 200.1 ± 0.03055 which is the most stable and favovorable characteristics of all formulations. The Transmission Electon Microscope (TEM) was used to check the morphology of Curcumin particles. It could be seen that the micelles formed were irregular spherical in shape and the analysis of TEM images reveals that each globule is surrounded by a thick layer that reduces the interfacial energy, and leads to the formation of barrier to coalescence.