Self nanoemulsifying drug delivery system of griseofulvin / Tazqirah Muhamad

The oral drug delivery is fraught with low and erratic bioavailability owmg to enzymatic degradation of drug, poor permeability, poor solubility and dissolution. The objective of the study was to develop and characterize Self Nanoemulsifying Drug Delivery System (SNEDDS) of Griseofulvin, a Biopharmaceutical Classification Scheme class II for improved oral delivery. The components for nanoemulsion were identified by solubility studies and tendency for self­ emulsification in various excipients. Castor oil, Cremophor RH40 and Labrafil were selected as oil, surfactant and co-surfactant respectively. The effects of varying ratios of surfactants:co-surfactants:oil ratios of SNEDDS were studied. Droplet size and zeta potential of the formulations were investigated. The SNEDDS exhibited good efficacy for self-emulsification.