Antioxidant activity studies in brain of male bisphenol A treated sprague dawley rats at different dose response / Siti Fatimah Mustafa Fadzil

Bisphenol A (BPA) is one of the most important monomer used in the production of polycarbonated plastic food and beverage containers, resin lining of cans, dental sealants and many other common household products. BPA is an environmental endocrine disruptor, which exerts weak estrogenic properties. As we used many of the BPA related items, we are highly exposed to this chemical. As BPA can cross the blood brain barrier, it might exert some harmful effect towards the brain. BPA is also known to induce the formation of reactive oxygen species (ROS). Antioxidant is the natural defense mechanism that protects the cells from functional and structural damages caused by the reactive oxygen species (ROS). Therefore, this research is conducted to study the effects of different doses of BPA on the antioxidant activity in the brain by measuring one of the enzymes that is glutathione peroxidase (GPx). The result shown no significant difference of the GPx activities when exposed to the different doses of BPA (p=0.526). However, more studies may be needed before concluding that there is no effect of BPA on the antioxidant activities in the brain.