Molecular docking study of quassinoids derivatives and mouse P-glycoprotein / Farahen Abd Hadi

P-glycoprotein is a multidrug resistance protein that caused the failure of chemotherapeutic treatments due to the protein overexpression in cancer cells. Quassinoid is a natural compound that exhibits an antileukernic activity which has potential to treat cancer disease. In this study, quassinoids derivatives are predicted to have potential interaction with the p-glycoprotein. The results from Autodock Vina presents the finding of interaction between quassinoids derivatives-P­ glycoprotein complexes. The results obtained show the quassinoids derivatives bind to amino acid residues GLN 986 of P-glycoprotein This study shows the potential interactions of quassinoids derivatives with P-glycoprotein.