Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun

Most of the liquid formulations are prepared in concentrations that are not suitable for administration to children. They have difficulty in swallowing drugs in solid dosage form such as tablets and capsules. To overcome this problem, drug suspensions are prepared extemporaneously by pharmacists by reformulating the drug from the solid tablet dosage form to the suitable desirable dosage for pediatrics. Captopril is one of the common extemporaneously preparation prepared for treatment of children with heart failure. The aim of this study is to identify the stability of captopril syrup 1 mg/ml prepared by Hospital Sungai Buloh and to quantify the captopril syrup 1 mg/ml using HPLC. The HPLC system with UV detector with 220 nm wavelength was chosen. The samples were analyzed at day7, 14 and 21. The formulation found to be stable at 21 days at room temperature. The captopril syrup concentration was decreased by 12% of the initial concentration after 7days.