Investigation of antibacterial activity of 3,4,5-trihydroxybenzohydrazide derivatives / Mohd Hafiz Abdul Latif

The establishment of new antimicrobial agents is crucial since a few species of bacteria has developed resistance to the older antimicrobial agents especially when it comes to clinically important pathogens. The antimicrobial activity of compounds with hydrazine as the functional group has not been extensively studied. In this study, the bacterial live cultures of four species of clinically important pathogens including Staphylococcus aureus and Pseudomonas Aeruginosa were tested with thirty-two derivatives of 3,4,5- trihydroxybenzohydrazide derivatives. Vancomycin is used as a control in this study. It was found out that only a few out of thirty-two compounds are showing the inhibition.