Determination of protein concentration changes and body weight changes in females sprague-dawleys (SD) rats treated with different doses of BPA / Shazwani Shaharruddin

Nowadays, the use of plastic material is increasing rapidly. BPA is one of the highest­ volume chemicals and is produced in excess of 6 billion pounds per year for use as the monomer that is polymerized to manufacture polycarbonate plastic food and beverage containers, the resin lining of metal cans, dental sealants, and as an additive in a wide array of other products. Until recently, BPA had been considered to be a very weak environmental estrogen because of its low ER affinity and because in many bioassays, BPA can be 10,000- to I 00,000-fold less potent than estradiol. Therefore, this research is carried out to determine whether low dose of BPA can induce protein concentration changes. Our result showed that BPA can induce protein concentration changes in female rats but the trend is inconsistent. BPA also has effect on weight of animal study. All the BPA dose used in this study induce weight gain higher than positive control treatment. Our study also showed that when increasing dose of BPA were given to SD rats, the female reproductive organ such as uterine horn and ovaries will increase in weight.