Paclitaxel loaded and surface coated polyacrylic acid-peg­-chitosan based nanoparticles for breast cancer delivery / Muhd Hazwan Zainal Abidin

Paclitaxel is one of best anticancer drugs, which has excellent therapeutic effects against a wide spectrum of cancers. The formulation of paclitaxel used in the currently clinical administration includes Cremophor EL, which has been found to cause serious side effects. Nanoparticle formulation of paclitaxel may provide an ideal solution to overcome this problem and achieve a sustained chemotherapy. Anticancer drugs, such as paclitaxel (PTX), are indispensable for the treatment of a variety of malignancies. However, the application of most drugs is greatly limited by the low water solubility, poor permeability, or high efflux from cells. Nanoparticles have been widely investigated to enable drug delivery due to their low toxicity, sustained drug release, molecular targeting, and additional therapeutic and imaging functions. A suitable management of the pharmaceutical property is needed and helpful to design a desired nanoparticulate delivery system, which includes nature of the carrier, particle size and size distribution, morphology, surfactant stabilizer according to the technique applied, drug loading ratio and encapsulation efficiency, and surface property, etc.