Estimation of amikacin pharmacokinetics in hospitalized pediatric patients / Fatin Fitra Idris

This study was conducted to analyse the effectiveness of pharmacokinetics monitoring as well as to establish a population pharmacokinetics in hospitalized pediatric patients which has been treated with amikacin. The data consist of I 04 pediatric patients including 77 of male patients and 27 of female patients. Population pharmacokinetics has been calculated by using one-compartment model. The patients' parameters such as body weight, gender, age and creatinine clearance (CrCl) were analyzed to identify their potential influence on amikacin pharmacokinetics. Analysis of the data showed the mean and standard deviation of Ke (0.119 ± 0.066), t1/2 (8.026 ± 6.239) and Vd (0.630 ± 0.993). This study indicates that this population has a wide inter-patient variability with the coefficient of variation showed (COY) for Ke = 54%, t1/2 = 72% and Vd = 157%. Therefore, individualized pharmacokinetics is very crucial among pediatric patients treated with amikacin in order to achieve therapeutic effect and ensuring minimal adverse effect.