Dose response study of bisphenol A (BPA) towards the induction of oxidative stress in the brain of female sprague dawley rats / Muhammad Solleh Rahim

Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins. BPA can induce oxidative stress of the rats. Chitra et al., (2003) reported that BPA elicit depletion of the antioxidant defense system and induces oxidative stress in the epididymal sperm of rats. This study investigated the modification of Bisphenol A (BPA) doses which is 50 µg/kg/day, 500 µg/kg/day, I 000 µg/kg/day and 5000 µg/kg/day and its effect to the oxidative stress in the brain of female Sprague Dawley (SD) rats. Rats were given four different doses of BPA, which are 50 µg/kg/day, 500 µg/kg/day, 1000 µg/kg/day and 5000 µg/kg/day by force feeding for two weeks. At the end of second week of treatment, female SD rats were sacrificed. Exposure to BPA reduced the ratio brain to body weight. Exposure to BPA decreased the wet weight of the brain, kidney and testis (Kabuto et al., 2003). However, it increased body weight of female SD rats after two weeks treatment. Unfortunately, levels of glutathione peroxidase (GPx) and antioxidant (AO) concentration were not change significantly. Level of GPx activity is p=0.358 while AO concentration is p=0.257.