Studies on the polymer solvent interactions in presence of the drug aceclofenac / Siti Syamimi Ambo Mase

The ultrasonic velocity and density of different proportion of polymeric aqueous solution - 9: I, 8:2 and 6:4 mixture (Methylcellulose (MC) and polyethylene glycol (PEG)) and (MC and hydroxylpropyl methylcellulose(HPMC)) beside 9:0.5:0.5, 8:1:1 and 6:2:2 mixture (MC, PEG and HPMC) at 298.15 Kin the absence as well as in the presence of drug have been measured. The ultrasonic velocity data are used to estimate various acoustic parameters such as Molar sound velocity (Rm), Acoustic impedance (z), Intermolecular free length (Lf), Relative association (Ra), Internal pressure (πi) and free volume (Vt). From the experimental density and molar sound velocity data, the apparent isentropic molar compressibility (Ks, Ø) and isentropic compressibility (β ad), have been evaluated. The result shows a negative value in apparent isentropic molar compressibility (Ks, Ø) and in both the internal pressure and the free volume. The ultrasonic properties in mixtures exhibit a maximum in ultrasonic velocity and a rrurumum in isentropic compressibility, relative association and intermolecular free length.