Antihepatotoxicity of clidermia hirta / Izana Nabilla Izaddin

This is a preliminary study which aim to observe the antihepatotoxic acnvity of Clidermia hirta. The aqueous extract of Clidermia hirta leave was evaluated for its toxicity and antihepatotoxic activity against acetaminophen-induced hepatotoxic in mice. Mice were given dose of extract 2500 mg/kg, lOOO mg/kg and 500mg/kg to determine the mortality rate which are I 00 %, 0 % and 0% respectively. Study is continued with antihepatotoxic study with 3 groups that consists of 6 mice each group. The groups are control (water+ acetaminophen) and 2 test (extract + acetaminophen) group which have 2 different extract dose. I 00 mg/kg and 50 mg/kg. The activity of the mice is evaluated by liver weight in gram per IO gram of bodyweight which is not so reliable to conclude any remarkable antihepatotoxic activity of this plant.