Gene expression changes in male reproductive system of time response bisphenol A (BPA) treated sprague­ dawley rats / Amilia Abd Razak

BPA is an environmental estrogen. It can leach from plastic tableware and from the coating of food and drink cans and orally exposing human being to the compound. This study was aimed to carry out a research on the gene expression changes in male reproductive system of time response Bisphenol A (BPA) treated Sprague-Dawley rats. Concern is mounting regarding the effects of BPA which is a high-production-volume chemical used in synthesis of plastics to the reproductive systems. 100 mg/kg/day of BPA was fed orally to juvenile male rats at the different time of exposure which is 7 days, 14 days and 28 days. Ethynilestradiol was used as the positive control in the study. Male Sprague­ Dawley rats PND 28 were treated with BPA to evaluate the gene expression changes of estrogen receptor (ER) a, ERP and also androgen receptors. It is expected that BPA will cause over expression of ERa and ERP and inhibition of androgen receptors. However, this result was not obtained due to lower RNA concentration extracted from the testes. BP A also was found to increase the body weight and reduced the organ weight, which is testis of the treated rats. It can be concluded that BPA will alter the body weight and also the testes weight of the treated rats.