Anti cancer activity of methanol extract of dicranopteris linearis / Sariki Nazri Salleh

The in vitro antiproliferative and methanol extracts Dicranopteris linearis, it partitions and fractions leaves were determined in the present study assessed using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. Interestingly, the methanol extract of D. linearis (DLME), it partitions (DLMEMp, DLMEHp and DLMECp) and fraction 4 exhibit cytotoxic effect against HL-60. Their respective IC50 were 25.5 µg/ml (DLME), 16.5 ug/mL (DLMEMp), 38.5ug/mL (DLMECp) and 37.5 ug/mL (DLMEHp) and F4 (19ug/mL). In addition, they also not show cytotoxic effect against 3T3 normal cell line, which indicate their safety. DLME, all partitions except DLMEHp (IC50 = 36ug/mL) and all fractions did not exhibit cytotoxic activity against A-549 cell line. Besides, all fractions except F5 (IC50 = l 9ug/mL) shows no cytotoxic activity against 3T3 normal cell line. In conclusion, methanol extracts D.linearis, it partition and fraction 4 posses potential anticancer properties against HL-60 (human acute promyelocytic leukemia) and DLMEHp show potential anticancer activity against A-549 (carcinomic human alveolar basal epithelial cells). Thus, further thorough studies in term of phytochemical screening are important.