Antiproliferative properties of chloroform extract of dicranopteris linearis leaves against selected cancer cell lines / Mohamad Yazid Mohamad Noh

The in vitro antiproliferative and chloroform extract Dicranopteris linearis and its fractions leaves were determined in the present study by using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. The chloroform extract of D. linearis exhibited inhibition of cell proliferation of HL-60 at concentration of 31.5 µg/ml but no anti­ proliferative activity detected when tested on A549 cells. Only DLF5was shown to be cytotoxic against HL-60 with IC50 value of 39.5 µg/ml while no fraction of D. linearis leaves seemed able to inhibite the proliferation of A549 cells. Interestingly, the extract and all fractions except DLF6 (IC50 = 4ug/mL) did not exhibit cytotoxic effects on 3T3 normal cells. In conclusion, the D. linearis leaves possessed potential anti-proliferative that could be attributed to its bioactive compounds within the leaves, thus, further study is needed to explore the lead compound liable for anti-proliferative activity from this plant.