Histological changes in male reproductive system of dose response bisphenol A (BPA) treated sprague-dawley (SD) rats / Muhammad Faiz Abdul Hadi

Bisphenol A (BPA) is a chemical produced in large quantities for use primarily in the production of polycarbonate plastics and epoxy resins. BPA is also act as potential endocrine disruptor which it mimics the action of estrogen and lead to disorder of reproductive system. In this study, four groups of SD rats were administered orally at different dose (50µg/kg/day, 500µg/kg/day, 1000µg/kg/day and 5000µg/kg/day) treatments for 2 weeks. Others groups of SD rats were administered orally with lOµg/kg/day of ethinylestradiol (EE) for 2 weeks. The observations and analysis made in this study was the determination of histological changes in the testis of SD rats when exposed to different doses. Testes were histologically examined by light microscopy at 8 weeks of age. Result indicates that at 50µg/kg/day, there were any no abnormalities found but at 500µg/kg/day, result indicates seminiferous tubule (ST) showing histological abnormality including some changes such as shape of ST was affected, wider interstitial space area was observed and also viewing loss of luminal space. At higher doses of 1000µg/kg/day and 5000µg/kg/day, the abnormality of ST is still observed. The results of the present study show that higher dose of BPA may cause more harmful effects to the SD rat male reproductive system.