In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin

Baharin, Siti Badariah (2009) In silico identification of plasmodium falciparum merozoite membrane proteins: a study of malaria vaccinology / Siti Badariah Baharin. Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).

Abstract

Malaria is a serious infectious disease that has contributes to high rate of mortality throughout the world. It is spread by Anopheles mosquitoes, which have been prior infected by Plasmodium parasites such as Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. The current scenarios of malaria are that the antimalarial drugs cannot provide sufficient treatment, and the vaccines available also could not give full protection. Therefore, this study is aim at using in silica software to analyze protein sequence whether it could be a candidate to produce an effective vaccine. The analysis of the Pf7 protein sequence of Plasmodium falciparum shows that this protein consists of 264 amino acids, with grand average ofhydropathicity (ORA VY) value of -0.824. The negative value indicates that this protein is hydrophilic. This protein is located extracellularly and secondary structure prediction shows that it consists of 46.8% coil, 23.8% sheet, 19.0% turns, and 16.9% helix. For antigen epitope prediction, the result shows that subsequence "FFIFVTFNf' has high probability as promiscuous binder. As the conclusion, results obtained from all of the analyses conducted for this Pf7 protein can act as preliminary information in designing actual candidate vaccine in the future.

Metadata

Item Type: Thesis (Degree)
Creators:
Creators
Email / ID Num.
Baharin, Siti Badariah
UNSPECIFIED
Contributors:
Contribution
Name
Email / ID Num.
UNSPECIFIED
Leow, Chiuan Yee
UNSPECIFIED
Subjects: H Social Sciences > HD Industries. Land use. Labor > Special industries and trades > Pharmaceutical industry
R Medicine > RS Pharmacy and materia medica > Materia medica > Pharmaceutical chemistry
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Pharmacy
Programme: Bachelor of Pharmacy
Keywords: plasmodium falciparum, merozoite membrane proteins, malaria
Date: 2009
URI: https://ir.uitm.edu.my/id/eprint/105347
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