Stability of extemporaneous preparation in Hospital Putrajaya / Fairenna Fairuz

The main objective of this study is to determine the expiry date of chloral hydrate elixir 200 mg/ml and sodium bicarbonate 5% ear drop. These are the extemporaneous preparations obtained from Hospital Putrajaya. This is achievable by examining the chemical, microbial and physical stability of the products. In this project, the chemical and microbial stability were examined according to the method described in British Pharmacopoeia (BP) 2007 and United States Pharmacopoeia (USP) 30. The method used to determine the chemical stability of chloral hydrate preparations cannot be performed as it is not suitable to determine the concentration of chloral hydrate in the preparation. The microbial stability testing for chloral hydrate showed that there were numerous microbial growths which may due to contamination of the products and materials.