Synthesis, characterization, and antibacterial activity of Cu (ii) and Ni (ii) transition metal complexes of nos tridentate schiff base derived from s-2-fluorobenzyldithiocarbazate with 5-chloroisatin / Nurul Amalina Arifin

A schiff base ligand, S-2-fluorobenzyl 2-(5-chloro-2-oxoindolin-3- ylidene)hydrazinecarbodithioate was synthesized via the condensation reaction between S-2- fluorobenzyldithiocarbazate and 5-chloroisatin. The Schiff base was reacted with Cu(II) and Ni(II) metal salts to produce metal complexes. The Schiff base and its metal complexes were characterized by elemental analysis and various physico-chemical techniques. The ligand was capable of being a versatile chelating ligand. It acted as a uninegatively charged bidentate ligand when it was bonded to Cu(II) ion via the azomethine nitrogen and thiolate sulfur. In the Ni(II) complex, it acted as a uninegatively charged tridentate ligand when it was bonded to the metal ion through carbonylic oxygen. Square planar geometry was assigned to the Cu(II) complex and Ni(II) complex exhibit the tetrahedral geometry. Antibacterial screening was done on the Schiff base ligand and its metal complexes. Cu(II) complex showed that it was moderately active against the Gram positive bacteria strain and Cu(II) complex also showed lower activity against the Gram negative bacteria strain. Both Schiff base ligand and Ni(II) complex showed no activity against the Gram negative bacterial strain.