Effects of diabetes mellitus on estrous cycle of wky rat / Siti Fatimar Russin

Recent laboratory and clinical studies suggest that Diabetes Mellitus induce alterations in neuroendocrine system may bring about pathophysiological changes that negatively affect sexual function of female WKY rats. However, these studies have been few in number and are limited in scope. We analyzed the effect of STZ induced diabetes on estrus cycle of female WKY rats. Diabetes significantly altered female reproductive cycle and level of reproductive hormone. Diabetes led to persistent diestrus, supported by decreased in levels of estrogen and luteinizing hormone, and increased in progesterone level. Diabetes alteration of female WKY may be due to failure of insulin metabolism and impaired insulin aromatase crosstalk.