Synthesis of naphthoquinone derivatives with some study on percentage rate of formation for pyridinium salt / Nor Zaimah Muhamad

The focus of this study was to synthesize naphthoquinone derivatives, 49 via pyridinium salt of phenacyl bromide, 48 and also study on percentage rate of formation for pyridinium salt. Phenacyl bromide and pyridine were refluxed for five days to formed pyridinium salt, 48. The percentage yield of pyridinium salt obtained was 99.3%. The salt, 48 then reacted with 2-methyl-1,4-naphthoquinone, 8 by stirring overnight. Then, followed by filtration, extraction of solvent, recrystallization and lastly the product obtained separated by column chromatography to separate the optical isomers which were yellow and red. The percentage yields of products, 49 were 49.5% in form of mixture yellow and red isomers. Then, the two isomers were analyse with NMR, FTIR, and melting point analysis.