Repurposing segesterone acetate (nestorone®) as a potential neuroprotective drug / Gurmeet Kaur Surindar Singh

Neurodegenerative diseases affect an estimated 30 million people worldwide, with the number expected to increase to 150 million by 2050. Alzheimer's disease (AD), Parkinson's disease, and amyotrophic lateral sclerosis are all neurodegenerative diseases characterized by the accumulation of misfolded protein aggregates in specific brain regions. The challenges in developing new drugs for neurodegenerative diseases, due to the costly and time-consuming nature of preclinical and clinical trials, exacerbate the escalating global health challenge. Consequently, drug repurposing, or the additional utilization of existing drugs, presents itself as a favourable option for addressing these challenges, especially given that their safety has already been established.