Anti–acne cream using clove (Syzygium aromaticum) extracts / Anis Safiyah Mohd Sani

Acne is a common skin issue caused by a microbial infection that requires antimicrobial treatments to cure. Synthetic antioxidants such as BHA and BHT widely used to treat acne which excessive used of BHA and BHT can give negative effects. Natural products have received a lot of interest as they have potential pharmaceutical possibilities due to their relative safety. Hence clove (Syzgium aromaticum) has been one of the natural ingredients that has potential to treat acne as they have antioxidant properties. The aim of this research study is to evaluate antioxidant properties of clove oil and develop Antiacne cream by using methanolic extracts. Clove extracts was prepared at different concentration (10 μg/mL, 20 μg/mL, 30 μg/mL, 40μg/mL and 50 μg/mL) in methanol and the antioxidant properties have been tested using DPPH Radical Scavenging technique and the total phenolic content was tested using Folin–Ciocalteau’s phenol reagent. The percentage inhibition of DPPH scavenging activities of Syzgium aromaticum was 63.73 %, 71.47 %, 71.95 %, 79.79 %, and 85.78 % at 10 g/mL, 20 g/mL, 30 g/mL, 40 g/mL, and 50 g/mL concentrations, respectively. The total phenolic content obtained in S. aromaticum extraction was 11.76 mg GAE/g. Different concentration of clove extracts 1%, 0.75% and 0.5% was prepared in 10g of base cream. Clove extracts possesses high antioxidant activity and small amount of total phenolic content. High concentration of clove extract used in anti – acne cream has high potential to treat acne.