Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi

Uzairi, Nor Aisah (2008) Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi. Degree thesis, Universiti Teknologi MARA (UiTM).

Abstract

Ethyl 6-(4-methoxyphenyl)-4-phenylcyclohex-3-en-2-one-l-carboxylate was synthesized through Michael addition and intramolecular aldol condensation (Robinson annulation) of 4-methoxychalcone with ethyl acetoacetate using a strong base, natrium hydroxyde (NaOH) as catalyst. 4-mthoxychalcone was first prepared by aldol condensation of 4-methoxybenzaldehyde and acetophenone. The percentage yield of 4- methoxychalcone was 98.65% and its melting point is 74-75°C. Then 4-Methoxychalcone was reacted with ethyl acetoacetate through Michael addition and aldol cyclization to form the final substituted cyclohexenone product in 79% yield. The melting point of the substituted cyclohexenone product is 108 - 110°C.

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Item Type: Thesis (Degree)
Creators:
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Email / ID Num.
Uzairi, Nor Aisah
UNSPECIFIED
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-, Yazan
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Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences
Programme: Bachelor of Science (Hons.)
Date: 2008
URI: https://ir.uitm.edu.my/id/eprint/102106
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