Uzairi, Nor Aisah
(2008)
Psynthesis of a substituted cyclohexenone via Michael addition and intramolecular aldol condensation (Robinson annulation) of chalcone with ethyl acetoacetate / Nor Aisah Uzairi.
Degree thesis, Universiti Teknologi MARA (UiTM).
Abstract
Ethyl 6-(4-methoxyphenyl)-4-phenylcyclohex-3-en-2-one-l-carboxylate was synthesized through Michael addition and intramolecular aldol condensation (Robinson annulation) of 4-methoxychalcone with ethyl acetoacetate using a strong base, natrium hydroxyde (NaOH) as catalyst. 4-mthoxychalcone was first prepared by aldol condensation of 4-methoxybenzaldehyde and acetophenone. The percentage yield of 4- methoxychalcone was 98.65% and its melting point is 74-75°C. Then 4-Methoxychalcone was reacted with ethyl acetoacetate through Michael addition and aldol cyclization to form the final substituted cyclohexenone product in 79% yield. The melting point of the substituted cyclohexenone product is 108 - 110°C.
Metadata
Item Type: | Thesis (Degree) |
---|---|
Creators: | Creators Email / ID Num. Uzairi, Nor Aisah UNSPECIFIED |
Contributors: | Contribution Name Email / ID Num. Thesis advisor -, Yazan UNSPECIFIED |
Divisions: | Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences |
Programme: | Bachelor of Science (Hons.) |
Date: | 2008 |
URI: | https://ir.uitm.edu.my/id/eprint/102106 |
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