Preparation of nanoparticles by using sucrose ester as an alternative surfactant / Abdul Fatah Hambali

Emulsion evaporation method can be used to prepare nanoparticles. In this study, sucrose ester (SE) was used as an alternative surfactant as it has low toxicity, excellent biocompatibily and biodegradability and provide alternative to the generally more convenient ethylene oxide (EO) based nonionic surfactants if compare to the usage of polyvinyl alcohol (PY A), which reported carcinogenic and lead to many unwanted effects. The formulation was assessed by using Zetasizer and scanning electron microscope. Results showed that at 0.05% (weight/volume) surfactant concentration with HLB 15 provided discrete and spherical nanoparticles if compare to the 0.01 % (weight/volume) and 0.1 % (weight/volume) surfactant concentration with HLB 15. This study may suggest that many options can be done in order to optimize the stability and the particle size of the particles which may be helpful in the development of nanoparticle systems for parenteral delivery of protein and gene medicines, by using SE as alternative surfactants.