Antinociceptive activities of aqueous extract of ficus deltoideae leaves in rats and mice / Suniza Basilon

Ficus deltoideae or “mas cotek” has been widely used in traditional medicine because of its beneficial and nutritious. The aqueous extract of Ficus deltoideae leaves was investigated for its antinociceptive activity in several in vivo experimental models. In this study we investigation on antinociceptive activity in mice and rats at doses of 100, 300, and 1000mg/kg subcutaneously using acetic acid-induced abdominal writhing, formalin and hot plate test to evaluate its analgesic activities. The result showed that intraperitoneal administration of Ficus deltoideae leaves aqueous extracts at all doses used which indicated the present of both peripherally and central mediated activities. In the acetic acid-induced writhing test, the result showed that the 300 and 1000mg/kg dose of extract exhibited significant (P<0.05) antinociceptive activity in a dose-dependent manner and both extract had 60.2% inhibition respectively compared to the control animals. Moreover, only the 1000mg/kg dose of AEFD in hot plate test exhibited significantly (P<0.05) increases the response latency time to the heat stimulus. In the formalin test, the extract produced a significantly (P<0.05) reduced paw licking of formalin-induced pain with early phase showed the highest 61.4% inhibition at 300mg/kg and late phase demonstrated highest 71.1% inhibition at 100mg/kg. The results demonstrate that Ficus deltoideae presents antinociceptive activity in mice and rats, which support its folkoric use as an analgesic.