Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman

Radman, Ekha Mardziah (2010) Effects of microwave on drug release responses of spray-dried alginate microspheres / Ekha Mardziah Radman. Masters thesis, Universiti Teknologi MARA.

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Abstract

The behavior of rigid guluronic acid-rich (MG) and flexible mannuronic acid-rich (MC) alginate in controlling drug release responses of spray-dried microspheres against microwave was investigated using sodium diclofenac as model water-soluble drug. MC microspheres required a shorter period of microwave irradiation to reduce drug release extent than MG microspheres. In response to microwave, the drug release profiles of 1:1 MG-MG microspheres resembled MC microspheres. The state of polymer-polymer and drug-polymer interaction via 0-H and/or N-H moiety of microspheres was affected by alginate chain flexibility under the influence of microwave. It then governed the drug release responses of microspheres.

Item Type: Thesis (Masters)
Creators:
CreatorsEmail
Radman, Ekha MardziahUNSPECIFIED
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy
Item ID: 4833
Uncontrolled Keywords: Drugs, Microwave, microspheres
Last Modified: 30 Aug 2018 04:30
Depositing User: Staf Pendigitalan 1
URI: http://ir.uitm.edu.my/id/eprint/4833

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