Synthesis of 3,4-dimethoxy-10-benzyloxystilbene / Hanisah Jan Abdul Shatar

The aim of the research is to synthesis 3,4-dimethoxy-l 0-benzyloxystilbene. In order to accomplish it, three established reactions have been used. Protection of 2-iodophenol with benzyl bromide as a protecting agent was the first step. Then, conversion of the 3,4- dimethoxybenzaldehyde to 3,4-dimethoxystyrene has been done via Wittig reaction. Finally. both compounds were coupled together in the presence of palladium chloride as a catalyst and methyl triphenylphospine iodide as a ligand through Heck reaction (0.8187 g; 73.9% yield). TLC, lH-NMR, UV, IR and melting point characterization were used for conformation the of the products. The stilbene, which is expected to be formed, was successfully synthesized.