Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek

Salleh, Mohd Zaki and Teh, Lay Kek (2010) Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek. [Research Reports] (Submitted)

Abstract

Tacrolimus is an immunosuppressant commonly used for long term in transplant patients to prevent organ rejection. Its use faces clinical challenges in achieving optimum dose for all patients. There are wide variation in doses of tacrolimus required for patients resulting in different drug levels and unpredictable drug responses. Certain patients are predisposed to an increased susceptibility to acute rejection while many are at risk of adverse effects of tacrolimus. Tacrolimus is a substrate for both P-glycoprotein (Pgp, encoded by the gene MDR1) and CYP3A's. Differences in the intestinal P-glycoprotein and hepatic and intestinal cytochrome P4503A activities have been postulated as contributing to the wide inter-patients variations in drug levels and responses. We therefore aim to investigate the impact of the genetic polymorphism as well as expression level of MDR1 in transplant patients receiving tacrolimus.

Metadata

Item Type: Research Reports
Creators:
Creators
Email / ID Num.
Salleh, Mohd Zaki
UNSPECIFIED
Teh, Lay Kek
UNSPECIFIED
Subjects: Q Science > QH Natural history - Biology > Genetics > Genetic polymorphisms
R Medicine > RD Surgery > Transplantation of organs, tissues, etc.
Divisions: Universiti Teknologi MARA, Shah Alam > Research Management Centre (RMC)
Date: 2010
URI: https://ir.uitm.edu.my/id/eprint/9751
Edit Item
Edit Item

Download

[thumbnail of LP_MOHD ZAKI SALLEH RMI 10_24.pdf] Text
LP_MOHD ZAKI SALLEH RMI 10_24.pdf

Download (1MB)

Digital Copy

Digital (fulltext) is available at:

Physical Copy

Physical status and holdings:
Item Status:

ID Number

9751

Indexing