Unravelling the mechanisms underlying the immunometablic changes in gestational diabetes mellitus animal model that is induced through biochemical, pharmacological and lifestyle factors / Siti Hajar Abdul Aziz

Gestational diabetes mellitus (GDM) is defined as diabetes that is not clearly apparent diabetes, diagnosed in the second or third trimester of pregnancy. Women diagnosed with diabetes during gestation have an increased incidence of complications during and after pregnancy. Thus, this study attempts to develop a GDM animal model in female Sprague-Dawley rats. This study comprises of two phases; first phase showed comparison between four groups with different diets with GDM fed with high fat sucrose diet group was chosen in GDM animal model in Phase 2 of this study, as the group show the relative elevated level of glucose and lipid profiles. Rats were fed with high fat sucrose diet, impregnated, and induced with Streptozotocin and Nicotinamide on (D0).