Investigation of nicotinamide: cinnamic acid and nicotinamide:p-coumaric acid cocrystals / Mohamad Nor Amirul Azhar Kamis

A pharmaceutical cocrystal is defined as a solid compound that contains two or more different molecular components, which able to modify the physicochemical properties of drugs. In this work, cinnamic acid (CIN), and j^-coumaric acid (COU) were employed as the coformers for the cocrystal formation with nicotinamide (NIC) as the active pharmaceutical ingredient (API). The cocrystals formations were studied using various feed molar ratios (1:1, 1:2, and 2:1) of API and coformer using different solvent (methanol, ethanol, and acetonitrile). The cocrystals formations were investigated through different solid state methods namely neat grinding, liquid-assisted grinding, and fast evaporation. The solid state samples were characterized using DSC, PXRD, and FTIR.