Role of angiotensin converting enzyme inhibitors in trabecular meshwork remodeling in ocular hypertensive rat / Tajul Atiqah Zaulkafali

Glaucoma is the major cause of an irreversible blindness worldwide and it is commonly associated with an elevation of intraocular pressure. ACE inhibitors have been shown to have ocular hypotensive effect in animals and human subjects. The aim of the study was to evaluate the ocular hypotensive effect and the effect on attenuation of trabecular meshwork remodelling by topical application of ACE inhibitor, enalaprilat dehydrate in chronic steroid-induced ocular hypertensive rat model. Ocular hypertension was developed in normotensive Sprague Dawley rats (100-120g) of either sex by topical instillation of dexamethasone 0.1%, 2 times daily for 36 days. The rats that developed more than 25% rise in IOP were considered ocular hypertensive.