Role of striatin and mineralocorticoid receptor (MR) in cardiovascular diseases / Burhanuddin Moizeze

Cardiovascular (CV) disease has been implicated as the leading cause of death and remains one of the most complex disease due to its pathophysiology involving multiple organs systems. One of the many causes of hypertension, the most common CV disease, is activation of mineralocorticoid receptor (MR) by aldosterone (ALDO). MR is a well-studied steroid hormone receptor and our laboratory has recently shown that MR co-immunoprecipitates with striatin, a novel scaffolding protein. Striatin potentially modulates MR's non-genomic functions. Furthermore, striatin polymorphism in humans is associated with salt sensitivity of blood pressure. Therefore, we investigated the role of striatin in modulating blood pressure along with modulation of MR's non-genomic functions using a genetically modified mouse model.