Mechanism of ocular hypotensive action of angiotensin converting enzyme inhibitor / Raja Nor Intan Safinaz Raja Mat Yassin

Angiotensin converting enzyme inhibitors (ACEIs) have been shown to reduce intraocular pressure (IOP), however, their mechanism of IOP reduction is poorly understood. The possible mechanisms of ACEIs action are include stimulation of the prostaglandin (PG) synthesis leading to increased matrix metalloproteinase (MMP) and TNF-alpha activities, as well as reduction of angiotensin II type one receptor activity in the trabecular meshwork. The objective is to evaluate the mechanism of ocular hypotensive action of angiotensin converting enzyme inhibitors.