Light microscopic study of hepato-renal lesion & their reversibility after long term administration of arsenic trioxide in Sprague Dawley rats / Siti Sarah Ahmad Shahidan

Background: Arsenic is widely distributed in nature in the form of chemical compound or metalloids. It is found to be mixed with drinking water of shallow natural reservoirs. Over 100 million people of the world are at risk of exposure to arsenic. It causes variety of pathologic conditions including cutaneous and visceral malignancies. 8-hydroxy-2-deoxyguanosine (8- OHdG) is one of the major reactive oxygen species, widely accepted as a sensitive marker of oxidative DNA damage. The reversibility in organ damage after arsenic exposure is unclear. Objective: To study the histomorphology and 8-OHdG expression in the liver and kidney of rats exposed to long term arsenic and observe its reversibility after arsenic withdrawal.