Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom

Shadom, Nordiyana (2012) Pharmacokinetics of gentamicin in pediatrics hospitalized patients / Nordiyana Shadom. Degree thesis, Universiti Teknologi MARA (UiTM).

Abstract

The purpose of this study was to study the effectiveness of pharmacokinetics monitoring and to establish a population pharmacokinetics in pediatric hospitalized patients. The data comprise of 34 patients; 23 of male patients and 11 of female patients. The TDM data that had been collected from these patients is 71 data. The patients had been divided into 3 group according to their age which is group 1 (6 months to 2 years), group 2 (2 years t0 5 years) and group 3 (5 years to 12 years). The patient parameters including body weight, gender, age, creatinine clearance (ClCr) and serum electrolytes were analyzed to identify their potential influences on gentamicin pharmacokinetics. The data was best described with a one-compartment model. The data analysis showed that there is a strong relationship between Ke and volume of distribution (Vd) with R2 value of 0.98, weight and clearance with R2 value of 0.99, and relationship between creatinine clearance (CrCl) and clearance of drug with R2 value is 0.917. The mean of Ke, t1/2 and Vd in this study, were 0.18 hour-1, 4.31 hour and 0.54 L respectively. This analysis indicates that this population has a wide inter-patient variability and it necessitate the practice of routine therapeutic drug monitoring to ensure minimal adverse effect and maximum therapeutic effect to the patients.

Metadata

Item Type: Thesis (Degree)
Creators:
Creators
Email / ID Num.
Shadom, Nordiyana
UNSPECIFIED
Contributors:
Contribution
Name
Email / ID Num.
Thesis advisor
Manan, Mohamed Mansor
UNSPECIFIED
Subjects: R Medicine > RJ Pediatrics
R Medicine > RL Dermatology > Materia medica and pharmacology
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy
Programme: Bachelor of Pharmacy (Hons.)
Keywords: Pediatric, aminoglycoside, gentamicin, pharmacokinetic, therapeutic drug, pharmaceutical care
Date: 2012
URI: https://ir.uitm.edu.my/id/eprint/66742
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