Thermodynamics and solute solvent interactions during solubility enhancement of Naproxen utilizing the combined use of cosolvent and surfactant / Nurul Nadiah Abd Rahim

The present study deals with the solubility enhancement of Naproxen by adopting the combined use of surfactant and co-solvent. The solubility studies revealed 436.39 fold enhancements in the solvent system containing 0.8% w/v of sodium dodecyl sulphate and 8%v/v ethanol. The free energy of transfer for the solubilization process has been calculated. The samples of the solubility study were further subjected to conductometric analysis. The conductivity data was further analyzed and the thermodynamic parameters were duly calculated. The enhancement of solubility was correlated with the thermodynamic parameters to elucidate the molecular processes in terms of solute solvent interaction.