Effect of Labisia pumila aqueous extract on the estrogenic activity and metabolic disease markers in bilateral ovariectomized rats / Siti Nuraida Kamaludin

Menopause is a permanent cessation that occurs in women in Malaysia is between 45
to 55 years old. It is often associated with increased body weight and body fat
distribution due to the deprivation of estrogen hormone. Labisia pumila is an herbal
plant that Malaysian women widely consume as a herbal tonic. This herb helps in
regulating menstruation, feminine vitality and hormonal imbalance. It is speculated to
exhibit phytoestrogenic activity that has similar structures to estrogen hormone. This
study was conducted to determine the antioxidant activities i.e., total phenolic and
flavonoids; and the present of polyphenols compound in commercially produced L.
pumila aqueous extract with excipients (LPE). The study also aimed to assess the acute
and subacute oral toxicity studies; and to evaluate the effects of supplementation of the
LPE on body weight changes, female reproductive hormone (estradiol, folliclestimulating
hormone, and luteinizing hormone) and metabolic disease marker (glucose,
insulin, adiponectin, leptin, and resistin) of menopause induced rats.