Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail

Yi Ern, Elizabeth Teng and Xixian, Hee and Ismail, Muhamad Fareez (2022) Inhibitory effect of oral thin films (OTFs) containing xylitol against streptococcus mutans / Elizabeth Teng Yi Ern, Hee Xixian and Muhamad Fareez Ismail. Science Letters (ScL), 16 (1): 13. pp. 124-136. ISSN (eISSN): 2682-8626


Dental Caries is a chronic disease affecting half of the global population, causing pain and discomfort due to progressive damage to the teeth. Whilst xylitol has been studied for its effect on dental caries prevention, current practices present few limitations for its successful oral delivery, including short residence time in the mouth and poor patient compliance. Recently, oral thin films (OTFs) emerged as an alternative to delivering xylitol in the oral cavity. This research aims to develop novel OTFs containing xylitol with extended-release properties (as determined by the disintegration time) and to investigate its effect on a cariogenic bacterial strain, Streptococcus mutans. The minimum inhibitory concentration (MIC) of xylitol was determined. Employing the microdilution broth method, the antibacterial activity of the oral thin films containing xylitol for oral S. mutans was performed with simulated salivary fluid, incubated at 1, 4, and 10 h. The MIC of xylitol was found at 10%. Meanwhile, there was no significant difference in the inhibition of S. mutans (p > 0.05) between the control, OTFs (10 h), and xylitol-OTF (1 h), with the latter, demonstrated only 16.58% inhibition. Interestingly, when compared to xylitol-OTF (1 h), xylitol-OTF showed significant inhibition (p < 0.05) to S. mutans after four h (+53.24 %) and almost a complete inhibition after ten h (-92.58 %). These results suggest that the OTFs demonstrated a gradual release of xylitol and inhibited oral biofilm formation by decreasing the growth of S. mutans in a time-dependent manner. Most importantly, the study indicated the successful development of a novel xylitol-OTF with potential as an oral health biotherapeutic agent.


Item Type: Article
Email / ID Num.
Yi Ern, Elizabeth Teng
Xixian, Hee
Ismail, Muhamad Fareez
Subjects: T Technology > TP Chemical technology > Synthetic products
T Technology > TP Chemical technology > Chemical engineering
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences
Journal or Publication Title: Science Letters (ScL)
UiTM Journal Collections: UiTM Journal > Science Letters (ScL)
ISSN: (eISSN): 2682-8626
Volume: 16
Number: 1
Page Range: pp. 124-136
Keywords: Xylitol, oral thin film, Streptococcus mutans
Date: January 2022
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