Integration of hyperelastic constitutive models in hybrid biomaterial for wound healing application / Nur Nabila Mohd Nazali

Mohd Nazali, Nur Nabila (2020) Integration of hyperelastic constitutive models in hybrid biomaterial for wound healing application / Nur Nabila Mohd Nazali. Masters thesis, Universiti Teknologi MARA.


Various type of healing patch in the current market such as acne patch were used daily
to reduce bacteria on the wounded area. Desired characteristics of wound dressing are
good absorption rate, reduce healing time and equipped with an antibacterial agent. In
this project, a perfect balance composition between natural biopolymer and mechanical
properties on the new wound-healing material is complicated to explicate. This research
focuses on the study of basic mechanical and biomechanical properties of the material
for a healing patch application with a new composition of biodegradable ingredients by
using the estimation of hyperelastic models to fit with the experimental data. This
project was started with material selection divided into three sets. Secondly, the three
sample sets undergo a uniaxial tensile test to obtain the raw data. For numerical phases,
the conventional theory of large deformation based on hyperelastic constitutive
equations and Stress-Strain Energy Theory were identified. The final step for this
project is curve fitting between experimental data (Ogden and Mooney-Rivlin
hyperelastic models). From the hyperelastic theory, new parameters were carried out
for healing patch materials made of hybrid nanogelatin biomaterials. Most of the curve
fit presented were follow the trends but there are slight differences due to different
composition of the material. Based on the three sample sets (Set A, Set B, Set C), the
best texture as artificial skin or healing patch is Set B. The Set B samples consist of
gelatin, glycerine, distilled water and aloe vera. For Ogden hyperelastic model, the
highest material constants obtained were α=1.8792 μ=0.1881 MPa from Set B

respectively with 500mm/min tensile speed. The highest material constants of Mooney-
Rivlin obtained were C1=0.0746 C2=0.1294 from Set C respectively with 500 mm/min

tensile speed. Based on curve fitting presentation, Ogden model is the suitable reference
for producing the future healing patch. As a conclusion, the suitable composition of a
healing patch was identified, the effect of basic mechanical and biomechanical
properties was explicated, and the parameter differences between hyperelastic models
were calculated. Therefore, the objectives were achieved successfully. The significance
of this project is we could reduce the exploitation of animal or human skin for
experimental skin purposes. In additions, the new technology could be improved in the
medical area with biodegradable and sustainable sources of healing patch.


Item Type: Thesis (Masters)
Email / ID Num.
Mohd Nazali, Nur Nabila
Email / ID Num.
Thesis advisor
Adull Manan, Nor Fazli (Dr. Ts.)
Subjects: T Technology > TP Chemical technology > Biotechnology > Processes, operations, and techniques
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Mechanical Engineering
Programme: Master of Science (Mechanical Engineering)
Keywords: Human skin; artificial human skin; wound healing; gelatin; dermatology
Date: August 2020
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