The elucidation of Dioscorea hispida's role in Molecular Oxidative Damage-mediated Toxicity in liver of meternal rats / Abdul Rahim Azlan

Azlan, Abdul Rahim (2016) The elucidation of Dioscorea hispida's role in Molecular Oxidative Damage-mediated Toxicity in liver of meternal rats / Abdul Rahim Azlan. Degree thesis, Universiti Teknologi MARA (Kampus Puncak Alam).

Abstract

Dioscorea hispida, or "Ubi Gadung", has been studied widely in ethnobotany, ethnomedicine, nutritional sources, toxic content, structure and metabolism process and process of removing toxic content. This yam contains highly toxic alkaloid known as dioscorine, and other toxic substances such as cyanide. These toxic contents have shown pathogenic effect to human. The yam is believed can induce oxidative stress which leads to DNA damage. This study is conducted by using ROS assay and comet assay. The results show the DNA damage is directly proportional to D. hispida concentration. The toxicity of D. hispida has potential to induce genotoxicity.

Metadata

Item Type: Thesis (Degree)
Creators:
Creators
Email / ID Num.
Azlan, Abdul Rahim
2013461444
Contributors:
Contribution
Name
Email / ID Num.
Thesis advisor
Md Saad, Wan Mazlina
UNSPECIFIED
Subjects: Q Science > QD Chemistry > Organic chemistry
R Medicine > RA Public aspects of medicine > Toxicology. Poisons
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Health Sciences
Programme: Bachelor of Medical Laboratory Technology
Keywords: Dioscorea hispida, Molecular Oxidative Damage-mediated Toxicity
Date: 2016
URI: https://ir.uitm.edu.my/id/eprint/55282
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