pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira

Valente Pereira, Rosa Elizabeth (2008) pH-sensitive nanoparticles as carriers for oral delivery of a model peptidomimetic drug / Rosa Elizabeth Valente Pereira. PhD thesis, Universiti Teknologi MARA.

Abstract

Peptide-related drugs are usually unstable in the harsh gastrointestinal environment with poor absorption throughout the gut. The potential of anionic pH-sensitive nanoparticles to act as novel drug carriers for oral administration of such compounds was investigated using a peptidomimetic drug, cefotaxime sodium. Drug loaded nanoparticles were prepared using a pH-controlled nanoprecipitation method. Three types of nanoparticles were prepared using different grades of Eudragit polymer, namely L100, L100-55 and S100. The drug-loaded nanoparticles have a size of about 100 nm, low polydispersity, encapsulation efficiencies of more than 50%, drug entrapment and drug content between 4-5%.

Metadata

Item Type: Thesis (PhD)
Creators:
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Valente Pereira, Rosa Elizabeth
UNSPECIFIED
Subjects: R Medicine > RM Therapeutics. Pharmacology > Drugs and their actions
R Medicine > RS Pharmacy and materia medica > Materia medica > Pharmaceutical dosage forms
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Pharmacy
Keywords: Peptide-related drugs, gastrointestinal environment, peptidomimetic drug, cefotaxime sodium
Date: 2008
URI: https://ir.uitm.edu.my/id/eprint/5480
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5480

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