Evaluation of blood coagulation activity in aqueous extract from the stem of mikania micrantha / Muhammad Syakir Mazlan

Mazlan, Muhammad Syakir (2019) Evaluation of blood coagulation activity in aqueous extract from the stem of mikania micrantha / Muhammad Syakir Mazlan. Degree thesis, Universiti Teknologi MARA ( Kampus Puncak Alam ).


Modern pro-coagulant drugs has unwanted side effects such as causing breathing difficulties and sensory problems. Thus, natural remedies such as the extract from the stems of Mikania micrantha could provide an alternative with less to no adverse effect. Mikania micrantha, which is considered as one of the worst weed in the world, has potential as a blood-clotting agent based on its traditional usage. Hence, aqueous extract was prepared using water via the decoction method. The concentrated extract was further serially diluted to prepare different concentrations using normal saline (12.5%, 25%, 50% and 100%) prior to coagulation assays (aPTT and PT tests). Commercial control plasma were added with the different concentrations of extract and their clotting time were recorded. For aPTT test, the extract was found to demonstrate significant reduction in clotting time for plasma added with 25%, 50% and 100% concentrations of extract. As for the PT test, only the plasma added with 100% concentration of extract was found to show significant reduction in clotting time. Therefore, observations from this study indicates that the aqueous extract from the stems of Mikania micrantha reduces the clotting time for both extrinsic and intrinsic pathways of the coagulation cascade. As such, the stems of Mikania micrantha has potential to be used as a blood-clotting agent.


Item Type: Thesis (Degree)
Email / ID Num.
Mazlan, Muhammad Syakir
Email / ID Num.
Thesis advisor
Mohamed, Emida
Subjects: Q Science > QH Natural history - Biology > Cytology > Cell populations
Q Science > QK Botany > Plant anatomy
Divisions: Universiti Teknologi MARA, Selangor > Puncak Alam Campus > Faculty of Health Sciences
Programme: Bachelor of Medical Laboratory Technology
Keywords: Blood-clotting agent, Mikania micrantha, aqueous extract
Date: 2019
URI: https://ir.uitm.edu.my/id/eprint/51616
Edit Item
Edit Item


[thumbnail of 51616.pdf] Text

Download (1MB)

Digital Copy

Digital (fulltext) is available at:

Physical Copy

Physical status and holdings:
Item Status:

ID Number




Statistic details