Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]

Rosli, Norsuhaila Rosmimi and Anuar, Tengku Shahrul and Adenan, Mohd Ilham and Mohd Janor, Roziah and Ahmad, Rohana and Teh, Lay Kek and Salleh, Mohd Zaki and Abu Bakar, Sahol Hamid and James, Richard Johari (2021) Association of COMT polymorphism and academic achievement among female undergraduate students / Norsuhaila Rosmimi Rosli ...[et al.]. Science Letters (ScL), 15 (2). pp. 90-101. ISSN 2682-8626

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Abstract

Academic achievement may be influenced by catechol-O-methyltransferase (COMT) polymorphism. A common functional polymorphism of COMT, the rs4680 is consistently being involved in the modulation of dopaminergic pathway and prefrontal cortex function which may predominantly affect cognitive functions. A total of 197 female participants were recruited in this study. The score of student’s grade point average (GPA) from the latest previous semester was used as the measurement of academic achievement. The COMT polymorphism was genotyped using tetra primer allele specific polymerase chain reaction. The findings indicated that there were 8 (4.1 %), 72 (36.5 %), and 117 (59.4 %) participants harbouring Met/Met, Met/Val, and Val/Val genotype for COMT polymorphism respectively. All the genotype distributions of COMT polymorphism were consistent with Hardy-Weinberg equilibrium (χ2 = 0.495, p > 0.05). The one-way analysis of variance (ANOVA) result demonstrated that participants bearing Met/Met genotype had a better achievement in GPA as compared to the other COMT genotypes (p = 0.001). These findings support evidence that the affective role of COMT polymorphism might overwhelm cognitive abilities in measures of academic achievement like GPA.

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Item Type: Article
Creators:
Creators
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Rosli, Norsuhaila Rosmimi
UNSPECIFIED
Anuar, Tengku Shahrul
UNSPECIFIED
Adenan, Mohd Ilham
UNSPECIFIED
Mohd Janor, Roziah
UNSPECIFIED
Ahmad, Rohana
UNSPECIFIED
Teh, Lay Kek
UNSPECIFIED
Salleh, Mohd Zaki
UNSPECIFIED
Abu Bakar, Sahol Hamid
UNSPECIFIED
James, Richard Johari
richard@uitm.edu.my
Subjects: L Education > LB Theory and practice of education > Performance. Competence. Academic achievement
L Education > LB Theory and practice of education > Educational psychology > Individuality
L Education > LB Theory and practice of education > School life. Student manners and customs. Students
Divisions: Universiti Teknologi MARA, Shah Alam > Faculty of Applied Sciences
Journal or Publication Title: Science Letters (ScL)
UiTM Journal Collections: UiTM Journal > Science Letters (ScL)
ISSN: 2682-8626
Volume: 15
Number: 2
Page Range: pp. 90-101
Official URL: https://scilett-fsg.uitm.edu.my
Item ID: 49119
Uncontrolled Keywords: COMT polymorphism, academic achievement, grade point average
URI: https://ir.uitm.edu.my/id/eprint/49119

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49119

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